Based on knowledge from greater than 3 million individuals over 50 years of age, UFSCar researchers and British collaborators confirmed the significance of this substance for muscular well being (picture: Freepik)
December 12, 2022
Maria Fernanda Ziegler | Agência FAPESP – A vitamin D has an necessary position to control the absorption of calcium and phosphorus by the organism, in addition to to maintain the mind and immune system functioning. And now researchers from the Federal University of São Carlos (UFSCar) and the University College London (Reino Unido) have proven that the substance additionally reduces the danger of muscle weak spot by 78% – a situation that no medical jargon calls dynapenia.
Essa fraqueza pode ser explicada partially pela atrophia muscular e é considerada um importante factoro de risco para a incapacidad física no égénagement. Pessoas com dinapenia têm maior incidence de quedas, hospitalização, institutionalização precoce e óbito prematuro.
No examine, printed no periódico Calcified Tissue International and Musculoskeletal Research, the researchers analyzed 3.205 Britons with greater than 50 years of age adopted by 4 years within the scope of the English Longitudinal Study of Aging (Elsa). O trabalho foi supported pela FAPESP.
“É sabido que a vitamina D participates in a number of capabilities in an organism. Ela verdade é um hormônio e entre suas diversas atuações está a reparação muscular e também a liberação de calcium para contrair o músculo [cinética da contração muscular]. Therefore, it was already anticipated that vitamin D provoked some muscular change and this was precisely what our examine proved”, he affirms Tiago da Silva Alexandreprofessor do Departamento de Gerontologia da UFSCar e orientador da pesquisa.
The scientist explains that the osseous and muscular tissues are interconnected not solely mechanically and bodily, but in addition biochemically. “Por esse motivo, endócrinos disturbances, como são os circumstances of deficiency and insuficiência de vitamina D, faverosem a perda de densidade mineral óssea, bem como a mécania de massa, força e fúnzione muscular”, diz.
No estudo, os researchers chosen people com mais de 50 anos que não apresentavam fraqueza muscular, ou seja, tiheman força neuromuscular maior ou igual a 26 kilos (kg) para homens and maior ou igual a 16 kg para mulheres. Essa medida é feita com um apparelo que afere a força de preensão guide, que tem uma boa correlação com a força world do organismo.
By following the members for 4 years, the researchers verified that those that had vitamin D deficiency originally of the examine (blood degree decrease than 30 nanomol per liter) introduced 70% extra danger of creating muscular weak spot on the finish of the examine than people who had regular ranges of vitamin D (nível sanguine maior que 50 nmol/L).
“This is a crucial discovering, as a result of it exhibits that vitamin D deficiency will increase the danger of muscular weak spot by 70%. However, as we all know that nobody on this planet has many circumstances of individuals with osteoporosis and that I take vitamin dietary supplements, we have to confirm the load of the complement,” says Maicon Luís Bicigo Delinocentebolsista da FAPESP e coautor do estudo.
Para tanto, os researchers retired from evaluation os people who had osteoporosis and faziam suplementação de vitamina D.
“Quando esses people had been retired from the evaluation, it was verified that those that had deficiency of vitamin D originally of the examine introduced 78% however danger of creating muscular weak spot. Já os com insuficiência [nível no sangue entre 30 e 50 nmol/L] presenteram 77% mais risco de desarrollo fraqueza ao last dos quatro anos de parlament quando comparatos àqueles que tiheman niños normais de vitamina D”, diz Delinocente.
Alexandre restalga que, com o resultado, foi possibile compador que não apenas a deficiency, mas também a insuficiência de vitamina D fazem com que o particular person tenha mais risco de developar fraqueza muscular.
“Another reflexo dos achados do estudo is the significance of changing vitamin D, when needed. The examine was finished with Britons and we all know that the photo voltaic incidence in Brazil is way larger than that in Great Britain, however the reality is that we even have a excessive incidence of vitamin D deficiency and insufficiency in Brazil and the world, primarily between us. Individuals mais velhos”, diz.
Alexandre reiterates that, para que corrra a sintez de vitamina D no organismo, é necessário tomar sol com áreas do corpo expostas. “Mas é preciso explicar para as pessoas que a suficiência e deficienção de vitamina D aumentam o risco de desarrollo perda de força muscular. Therefore, it’s essential to say that these individuals want to reveal themselves extra to the solar, to comply with a weight-reduction plan with meals wealthy in vitamin D, or to complement and apply train resistance to keep up power,” he concluded.
O article Are Serum 25-Hydroxyvitamin D Deficiency and Insufficiency Risk Factors for the Incidence of Dynapenia? pode ser lido em: https://hyperlink.springer.com/article/10.1007/s00223-022-01021-8.
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