Understand the new wave of obesity drugs

When it involves weight reduction, the most conventional technique of weight reduction is a caloric deficit, together with a diverse and nutrient-dense food plan along with common bodily train. Although the system appears easy, it isn’t straightforward to succeed in the anticipated consequence.

To assist individuals with obesity who’re unable to drop pounds, it has been discovered that some drugs initially designed for diabetics may help management urge for food and cut back the quantity of meals eaten.

In Brazil, though there is no such thing as a particular indication for obese, Ozempic (semaglutide) is the hottest choice. However, Mounjaro (tirzepatida) is awaiting authorization from Anvisa to enter the market and has additionally proven good ends in medical research with overweight individuals.

Both are promising drugs for bettering metabolic well being, decreasing weight and blood sugar, and stopping cardiovascular occasions, together with coronary heart assaults and strokes.

But what’s the distinction between the two cures? Endocrinologist Bruno Babetto, specialist in metabolism, explains what it is advisable find out about Ozempic and Mounjaro earlier than beginning any remedy. Check out:

1. What it is advisable find out about obesity drugs?

“The most essential factor is to comprehend that it isn’t a magic weight reduction answer. Ozempic and Mounjaro are drugs that assist to drop pounds and keep wholesome habits, however don’t cut back the quantity on their very own”, explains the knowledgeable. They state that they need to be mixed with different techniques to assist metabolic well being, akin to dietary modifications, train and satisfactory sleep.

2. What is the distinction between the two drugs?

Ozempic is a drug primarily designed to manage sort 2 diabetes in adults and needs to be used together with food plan and train. It has been obtainable in Brazil since 2018 and may solely be marketed with a prescription. The drug is injected underneath the pores and skin of the stomach, thigh, or higher arm, and the dosage is weekly.

In observe, endocrinologists have additionally prescribed semaglutide to deal with sufferers with obese or obesity – a power illness that opens the door to many different issues akin to hypertension, diabetes, excessive ldl cholesterol and triglycerides, fatty liver, coronary heart illness, sleep apnea. And most cancers too.

The drug will not be but formally really useful for the remedy of obesity or weight reduction in Brazil. But, in keeping with Babetto, in the United States, drugs with the energetic ingredient semaglutide are already authorised to be used by overweight or obese people who find themselves not diabetic.

The physician believes that use for related functions will quickly be authorised in Brazil, as research present that the drug results in a 15% discount in physique weight in obese and overweight sufferers over a 12 months and a half.

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Mounjaro, with the energetic ingredient tirzepetide, can also be an injectable pen designed to deal with sort 2 diabetes. It is a new drug and nonetheless underneath evaluation by Anvisa, not licensed to be used in Brazil for any situation. The drug has additionally proven good outcomes for treating obesity in different nations.

“When we eat, our physique releases two hormones: GIP and GLP-1. They inform the pancreas to launch insulin and stimulate emotions of satiety. These substances assist us digest meals correctly and hold blood sugar secure. And that is the place tirzepetide may help, as a result of it mimics what GIP and GLP-1 do naturally in the physique, contributing to emotions of satiety and consequent weight reduction,” says Babetto.

Research already reveals that tirzepartida could cause weight reduction that’s obtained via bariatric surgical procedure, an invasive process that may carry dangers. For this purpose, the chance of utilizing remedy as an alternative of a bariatric process is being studied.

3. Can I exploit Ozempic just for weight reduction?

You can, however by no means by yourself. The physician explains that, regardless of not being authorised by the regulatory company for use for weight reduction, Ozempic confirmed optimistic ends in analysis that evaluated its effectiveness in overweight sufferers.

But the knowledgeable factors out that, earlier than utilizing the drug as an “off-label” choice for weight reduction, “the affected person ought to endure rigorous evaluation and medical follow-up”. There is an understanding amongst endocrinologists that individuals with a physique mass index (BMI) of 28 and extreme obesity needs to be prescribed the drug.

4. What are the contraindications?

In no case ought to the drug be utilized with out medical supervision or indication, as the dosage and period of remedy are completely different for every affected person. Unsupervised use can have severe penalties, akin to extreme allergy symptoms to components and unintended effects akin to diarrhea, vomiting, nausea, and regaining misplaced weight.

In addition, it’s contraindicated for pregnant ladies, lactating ladies, individuals with liver or pancreatic issues, or these with a household historical past of most cancers akin to the thyroid.

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